University of Minnesota
University of Minnesota

Blazar Laboratory

Research in immunobiology and transplantation

Current Projects

Dr. Tolar's Research

Dr. Tolar’s research interests include:

  • Integrating clinical observation, molecular biology, immunology, and laboratory research in studying and treating children with lethal diseases—epidermolysis bullosa, bone marrow failure, peroxisomal and lysosomal inborn errors of metabolism, cancer and other devastating disorders.
  • Developing cellular therapies (including mesenchymal stromal cells and cellular reprogramming).
  • Improving the safety of existing therapies (hematopoietic cell transplantation and its conditioning regimens).
  • Investigating mechanisms by which stem cell transplantation is effective in repair of damaged tissues (e.g., heart, skin and brain).

Clinically, Dr. Tolar is currently working on protocols using hematopoietic stem cell transplant as a treatment for epidermolysis bullosa, dyskeratosis congenita, severe aplastic anemia, Fanconi anemia, mucopolysaccharidosis type I – Hurler syndrome, and adrenoleukodystrophy.