University of Minnesota
University of Minnesota
http://www.umn.edu/
612-625-5000

Blazar Laboratory

Research in immunobiology and transplantation

Current Projects

Regulatory T Cells (Tregs)

We have developed new approaches to propagate and expand CD4+25+ Tregs that can suppress alloresponses and GVHD. We are analyzing and manipulating the biochemical, molecular, cytokine and cell surface factors that regulate murine and human thymic-derived and peripheral inducible Treg development, expansion and function in vitro and in vivo. The in vivo biological effects of our immune manipulations are being monitored using in vivo 2-photon, bioluminescent and fluorescent stereomicroscopic imaging. Some of these studies have been translated into the clinic.