University of Minnesota
University of Minnesota

Blazar Laboratory

Research in immunobiology and transplantation

Current Projects

Graft Versus Leukemia (GVL)

Projects are ongoing to identify the host mechanisms responsible for tumor-mediated immune suppression of endogenous T effector cells, focusing on negative regulators of immune response. T cell immune therapy is used in combination with approaches that dampen the host immune suppressive response, cause homeostatic expansion of T cells via the induction of lymphopenia, target tumor cells or support T cell recruitment and survival within secondary lymphoid organs are being explored.