University of Minnesota
University of Minnesota
http://www.umn.edu/
612-625-5000

Blazar Laboratory

Research in immunobiology and transplantation

Current Projects

Graft-Versus-Host Disease

GVHD is a multi-organ system disorder in which donor T cells recognize host alloantigens present on antigen-presenting cells and tissues in the context of an inflammatory response. Studies are directed toward identifying and modifying signals that drive or inhibit GVHD generation. These include the analysis of costimulatory molecules and negative regulators of the immune response, metabolic stress responses, and local gut environmental factors that regulate GVHD. We are examining cell-based therapies such as regulatory T cells (see below) and myeloid-derived suppressor cells. We have also used a newly developed model of chronic GVHD that results from T:B cooperativity, leading to alloantibody and subsequently, collagen deposition, culminating in multi-organ system injury and pulmonary and liver fibrosis.