University of Minnesota
University of Minnesota

Blazar Laboratory

Research in immunobiology and transplantation

Current Projects

Genetic manipulations and reprogramming of immature and mature cells

We are using gene transfer approaches to introduce transcription factors and cytokine genes into thymic progenitor cells to stimulate thymic epithelial cell signaling, reprogram mature T cells and regulatory T cells into pluripotent stem cells, understand and manipulate mature regulatory T cells, and to examine transcription factors and epigenetic modification process involved in definitive vs non-definitive hematopoiesis.